News Origin

from the United States, Germany more than 40 countries such as Research found that there are 10 kinds of gene mutations can interfere with the rhythm of the heart beat and laws This abnormal rhythm may lead to serious heart disease, and may even trigger a sudden death .

some studies have shown that these genes lead to abnormal heart attack, but the rest of the selected genes was found after nearly half of heart disease-related. expert pointed out that there are some patients with heart disease is not high cholesterol levels, or obesity, so analysis of its gene may be help to understand the causes of their heart.

Zhang Yuan: Master Instructor, Beijing University of the Third Hospital Heart medicine Director physicians, the Chinese Medical Association Association of Pacing and Electrophysiology Electrophysiology youth members

them in their prime of life, in their prime, examination , they may also healthy than you. However, they are suddenly sudden death, mostly death without warning or symptoms sometimes occurred in rest or sleep, and no autopsy also found. This threat can be passed from generation to generation.

This is what kind of disease it?

consecutive months, since many young people have been reports of sudden death, from teens to 20 ranging from a few, it is the same age spent. This led to discussion of sudden death.

recently, from the United States, Germany and other countries, researchers found that 10 kinds of new new gene mutation, these mutations would seriously interfere with normal heart beat frequency and rhythm, and induced sudden death. This was found to enable the public to genetic tachycardia arrhythmia led to the sudden death of a great deal of concern given.

but the researchers also pointed out that the above-mentioned 10 kinds of genes in a single mutations does not necessarily lead to increased risk of arrhythmia, the next phase of the experts will focus on analysis of the above-mentioned 10 kinds of genetic variation in how much increase the extent of heart disease, and even lead to sudden death.

interpret the mechanism of ion channels are to blame

Peking University Third Hospital medical director of cardiac physician Dr. Zhang Yuan explained that the myocardial cells of each there are a lot of the surface known as "ion channel" of the micropore. Ion channels by protein composition, can open and close the channel to control sodium charged, calcium , as well as potassium ions out of . Ions have access to the so-called electrical activity of myocardial cells.

electrical activity that trigger further contraction activity of myocardial cells. Generally speaking, such electrical activity would be an orderly transfer in myocardial cells, thereby enabling the heart to complete the normal function of ejection.

channel gene mutations lead to degeneration

genetic arrhythmia syndrome gene mutations in patients with its control of cardiac ion channel encoding characteristics of the change occurred. When the abnormal ion channel function, the high-risk cardiac electrical activity disorder, thereby affecting the heart beat, premature ventricular contractions occur, ventricular tachycardia and even ventricular fibrillation. The event of cardiac rhythm disorders, myocardial cells will no longer be the coordination of contraction. human blood cycle disorder occurs, the loss of effective blood supplementary organs, resulting in syncope or sudden death.

four killers

said Zhang Yuan, is currently widely recognized internationally, and made it clear the name of hereditary ventricular There are four kinds of tachycardia syndrome, including the long QT syndrome, short QT syndrome, catecholamine布鲁达格sensitivity syndrome and polymorphic ventricular tachycardia, in which the most common long-QT syndrome. They are hereditary diseases, the existence of one or more gene mutations. Cardiac anatomy in general, there is no structural abnormalities visible to the naked eye, but because of genetic abnormalities occur, resulting in myocardial cells of the properties of ion channels changes in a variety of high-risk malignant ventricular arrhythmia. If not found, or too late will lead to timely treatment --- the sudden death of the deadly consequences.

long QT syndrome

doctor said Zhang Yuan, QT interval is ECG on the parameters of a measurement. The so-called "long QT syndrome" refers to not only the ECG in patients with prolonged QT interval, and clinical symptoms , the performance of as palpitation, syncope precursor, syncope attack or sudden death. Many patients are congenital, which means that they are born suffering from the disease, and is accompanied by life-long.

currently found 8 gene mutation can lead to congenital long QT syndrome, It is interesting that different gene mutations, the incentive for patients, the performance and response to drugs are different. As long QT1 type, there are KCNQ1 or KvLQT1 gene mutations, in patients with ventricular tachycardia and more especially as a result of movement swimming -induced; long QT2 type KCNH2 (or HERG) gene mutations in patients with more emotional when the incidence of resting or, if they were the voice of awakened sleep, the occurrence of malignant ventricular arrhythmia will lead to the possibility of sudden death greatly increased, so they put the room to avoid telephone and alarm clock; the existence of long QT3 type of SCN5A gene mutation, patients with rest or sleep more than in sudden death when the incident occurred, silent death.

Brugada syndrome

1986 years Brugada brothers observed a 3-year-old boy in Poland recurrent syncope and sudden death, repeated the success of the recovery of his father, The boy without organic heart disease. His sister have the same clinical manifestations, sudden death occurred when 2-year-old. Brugada and other later in 1992 summed up the first reported eight cases of patients with similar clinical features, attracted wide attention in 1996, the disease was named for the Brugada syndrome.

"the disease has also been domestic report ," Dr. Zhang Yuan said, "This is a hereditary disease, occur in young men, many of sudden death during sleep occurred at night. At present, only has been confirmed by a pathogenic gene SCN5A gene. "

short QT syndrome

and long QT the other hand, short-QT syndrome ECG on the QT interval than the normal short, Dr. Zhang Yuan said: "This is a very rare genetic disease, few reports of domestic-related, the current three gene mutations found associated with it."

catecholamine-sensitive polymorphic ventricular tachycardia

Dr. Yuan Zhang told reporters that catecholamine stress in the body, emotional state of excitement or movement by the adrenal gland to release a class of chemical substances. Under normal circumstances, its role in the cardiovascular system causing rapid heart beat, blood pressure increased. Epinephrine is a typical representative of ordinary people in the physical movement or emotional stress increase the secretion. Such patients in sports or emotional, a large number of release of catecholamine-induced ventricular tachycardia, known as the multi-sensitivity of catecholamine ventricular tachycardia. Catecholamine-induced polymorphic ventricular tachycardia is also a hereditary disease, gene mutations are now clear, including RyR2 and CASQ2. Clinically, this can co-exist in patients with a variety of arrhythmias, such as to capture the atrial arrhythmia, but also capture the ventricular arrhythmia. Most patients will appear in childhood syncope symptoms.

early detection of response to death threats

"Although aware that these are genetic diseases, but genetic testing are also research for the purpose, has not yet embarked on the clinical. "Dr. Zhang Yuan said.

However, if there is abnormal electrocardiogram, as well as have occurred in unexplained syncope or sudden death was the success of the recovery of patients and their families must go to the hospital in detail check .

of people have been diagnosed, lifestyle changes and treatment measures will help to prevent the danger, thereby prolong life. In ordinary life, must avoid strenuous exercise, physical activity and emotional excitement, to sleep in order to maintain a quiet room. Some patients taking a β-blocker known as the heart drugs to be effective in controlling the disease. Of course, embedded cardiac defibrillator is still the most effective treatment. It can be in ventricular tachycardia and ventricular fibrillation episodes, the automatic recognition of arrhythmia, the defibrillator to restore normal heart throb. But you have to check more than one you have "health" of the people placed in the body of a foreign body, it is indeed difficult.

read the anti-extension of the attention of the sudden death of 9

1. Regular medical check-ups: Regardless of the health of patients with heart disease or who should conduct regular physical examination, especially heart device quality of sexually transmitted diseases changed, but obvious symptoms of middle-aged.

2. To quit smoking: the incidence of coronary heart disease in smokers than non-smokers 3.6 times high.

3. Reasonable diet : high-protein, easy to digest the Food , such as fish, chicken, milk , soybean and so on.宜吃plant oils such as peanut oil, rapeseed oil, corn oil, more food rich in dietary fiber of coarse grains, vegetables , increased vitamin of the intake, eat more fresh fruits, sweets control, low-salt diet, eat less fried , fried, smoked, grilled and marinated food .

4. The prevention of obesity: obesity to the cardiovascular system adversely burden, weight 5 kg overweight, the burden of the heart that is increased by 10%.

5. The original disease treatment: such as high blood pressure , such as coronary heart disease.

6. To avoid the spirit of over-stretched: the spirit of excessive tension, agitation is likely to cause diseases such as coronary heart disease.

7. To have the law of life: time to get up on time and sleep, regular meals, regular exercise, adequate rest and not do any work.

8. Regular exercise: the right amount of physical exercise can improve cardiovascular function, walking is the most simple and safe movement.

9. Others: cold warm, guard against cold. Stool to maintain patency.

News Origin

from the United States, Germany and other countries more than 40 Research found that there are 10 kinds of mutations interfere with the rhythm of the heart beat and laws, such cardiac abnormalities may lead to serious heart disease, and may even trigger a sudden death .

some studies have shown that these genes lead to abnormal heart attack, but the rest of the selected genes was found after nearly half of heart disease-related. expert pointed out that there are some patients with heart disease is not high cholesterol levels, or obesity, so analysis of its gene may be help to understand the causes of their heart.

Zhang Yuan: Master Instructor, Beijing University of the Third Hospital Heart medicine Director physicians, the Chinese Medical Association Association of Pacing and Electrophysiology Electrophysiology youth members

them in their prime of life, in their prime, examination , they may also healthy than you. However, they are suddenly sudden death, mostly death without warning or symptoms sometimes occurred in rest or sleep, and no autopsy also found. This threat can be passed from generation to generation.

This is what kind of disease it?

consecutive months, since many young people have been reports of sudden death, from teens to 20 ranging from a few, it is the same age spent. This led to discussion of sudden death.

recently, from the United States, Germany and other countries, researchers found that 10 kinds of new new gene mutation, these mutations would seriously interfere with normal heart beat frequency and rhythm, and induced sudden death. This was found to enable the public to genetic tachycardia arrhythmia led to the sudden death of a great deal of concern given.

but the researchers also pointed out that the above-mentioned 10 kinds of genes in a single mutations does not necessarily lead to increased risk of arrhythmia, the next phase of the experts will focus on analysis of the above-mentioned 10 kinds of genetic variation in how much increase the extent of heart disease, and even lead to sudden death.

interpret the mechanism of ion channels are to blame

Peking University Third Hospital medical director of cardiac physician Dr. Zhang Yuan explained that the myocardial cells of each there are a lot of the surface known as "ion channel" of the micropore. Ion channels by protein composition, can open and close the channel to control sodium charged, calcium , as well as potassium ions out of . Ions have access to the so-called electrical activity of myocardial cells.

electrical activity that trigger further contraction activity of myocardial cells. Generally speaking, such electrical activity would be an orderly transfer in myocardial cells, thereby enabling the heart to complete the normal function of ejection.

channel gene mutations lead to degeneration

genetic arrhythmia syndrome gene mutations in patients with its control of cardiac ion channel encoding characteristics of the change occurred. When the abnormal ion channel function, the high-risk cardiac electrical activity disorder, thereby affecting the heart beat, premature ventricular contractions occur, ventricular tachycardia and even ventricular fibrillation. The event of cardiac rhythm disorders, myocardial cells will no longer be the coordination of contraction. human blood cycle disorder occurs, the loss of effective blood supplementary organs, resulting in syncope or sudden death.