People's lives depend on all the body organs to transport oxygen and nutrition component of the vascular network, and the vascular network growth, or rupture of blood vessels recovered from the two known as "growth switch" decision of the protein, which is Germany's Max Planck Institute of Molecular Biology of Medicine study and the University of Munster, a new study found that the papers published in the latest issue of the "cell" magazine, the mechanism of this medicine for the treatment of cancer and is expected to cardiovascular disease .

It's easy to wind, such as cardiovascular disease or myocardial infarction in the blood vessels that transport function of the importance of human health, researchers in Germany for decades has been studying the re-growth of blood vessels and organ repair injury, for example, by building new blood vessels, re-activation of tumor organ damage after surgery. Germany's Max Planck Institute of Molecular Biology and the University of Munster Medical researchers found that the decision is the first time the growth of blood vessels, "switch" has been named the "Notch" the "switch" is a blood vessel attached to the cell surface of body, the so-called endothelial cells. This receptor can be adsorbed on the surface of different proteins, the "switch" in the on or off position.

the biochemical mechanism of the individual components have been clear that the "switch" in a related state, the surface receptor Notch is as Arabic numerals, like the triangle protein 4 (the D114) and the growth factor VEGF impact. "Switch" in the open state, subject to the same surface protein is a protein jagged "Jagged1" impact.

person in charge of the project, the Max Planck Institute of Molecular Biology Medical拉夫亚Adams said: "We are the first of these individual components to understand how the role of, Jagged1 protein as the switch is open completely new understanding. In the next test in mice, we will learn more about the growth of blood vessels and the development of new drugs can be used in the human body. "

inhibit the growth factor VEGF has been applied for many years in the treatment of cancer and special Eye surgery, but this treatment is very expensive, affordable only a small number of patients. Max-Planck-Institute for Molecular Biomedicine in迪特博士cell biologist鲁伊贝added: "Because VEGF can increase vascular permeability and lead to bleeding, this factor can not be used for the treatment of vascular growth, by of Jagged1 understanding of protein function, we expected to find a new alternative treatment. "