U.S. Research found that the complexity of specific sugar molecules (polysaccharides) of breast cancer and prostate cancer play inhibition. The findings help to understand the complex carbohydrates in cancer in the role played by color , for cancer treatment specified in a new direction. The results of the study published in the recent "The United States National Academy of Sciences" on.

Burnham Institute for Medical Research of the U.S. scientists have found that polysaccharides can be combined with laminin, and attached to the cell surface α-DG protein. This combination helps to enhance epithelial cell adhesion and basement membrane cells and prevent cell transfer. Enzyme called β3GnT1 together with control of gene LARGE/LARGE2 bind laminin synthesis of polysaccharides. β3GnT1 downward will reduce the number of polysaccharides, resulting in breast cancer cell proliferation activities of capacity. When the researchers β3GnT1 forced expression of aggressive cancer cells, the binding of laminin polysaccharide will be restored, the rate of tumor formation will drop.

research team using antibodies to normal cells and cancer cells in α-DG and the expression of polysaccharide analyzed. It was found that two types of cells the number of α-DG similar, but the cancer cells more than the number of PG are significantly reduced. Further studies have shown that prostate cancer cells in α-DG in the polysaccharide more cancer cells formed tumors less. Research team also found that RNA interference through expression β3GnT1 stop, even if over-expression of LARGE, the number of polysaccharide will fall.

leader of the research group is Professor Fukuda, β3GnT1 have a role in tumor suppression, therefore, likely to be β3GnT1 raised a new means of cancer treatment.