Japan

recently that some type of influenza virus H1N1 variant has emerged. Director of Science and Technology Department of Guangdong Province in Li Xinghua, at the "Pearl of international bio-pharmaceutical industry development forum," revealed a spin-off Guangdong flow variation of the virus strain has not yet been found of "Tamiflu" is still sensitive. In addition, the South China Agricultural University have successfully Research a new anti-influenza medicine "peramivir" synthesis methods, but also greatly reduces the cost of synthesis.

Guangdong highly homologous to a strain flow

Li Xinghua, the province set up years ago people were suffering from infectious diseases, animal science and technology experts Group, the nation imported since the epidemic of influenza type H1N1, the provincial Science and Technology Agency emergency initiated the "animal people were suffering from Type A H1N1 influenza emergency special study."

Group May 21, following the success of the first case of isolated influenza H1N1 in Guangdong Province after the influenza virus, but also be imported from Guangdong Province, the second generation of cases and isolated cases of multiple strains of influenza A H1N1 influenza virus and completed a series of study isolates. Which completed a three alpha Guangdong H1N1 influenza virus isolates from the whole-genome sequencing.

experts in Guangdong Province-wide gene isolated from eight gene segments at home and abroad with 275 isolates of influenza virus subtype was found, and their homology higher than 99% on cases in Guangdong Province the same sources of pathogens are present in the new global epidemic of influenza virus type H1N1, in the course of HIV epidemic has yet to mutate. However, individual isolates from Guangdong Province, a receptor binding site mutation, and its biological significance remains to be clarified.

"peramivir" cost synthesis dropped

in drugs, "peramivir (Peramivir)" is in addition to "Duffy" and "flu-ching music" outside of a new type of anti-influenza drug. It is a new type of influenza virus neuraminidase inhibitors can effectively inhibit various strains of influenza virus replication and dissemination process.

South China Agricultural University College of Veterinary Medicine have successfully developed Pharmacological Research "peramivir" synthesis methods, so that total yield increased to 52%, a reduction of expensive reagents and the use of toxic reagents, significantly Synthesis of reduced costs. Group also studied the effect of anti-influenza drug, results show that the "peramivir" in mice infected with H9N2 avian influenza virus subtypes have a good role when conditions allow determination of its anti-influenza A H1N1 influenza virus effect.

In addition, the study found that all the virus isolates in Guangdong are against the flu drug "Tamiflu" and "zanamivir" sensitive, but have been amantadine resistance mutation.

pay close attention to the development of new vaccines Huanong

with the WHO recommended 1997-2010 influenza vaccine strains in the seasonal comparison, the Guangdong isolates low genetic homology (about 81%), antigenic variation of a larger point, suggesting that vaccination against seasonal influenza vaccine this flu is not an effective immune protection.

new vaccines in the research of animal origin in Guangdong Province zoonoses prevention and control of key laboratories (based on South China Agricultural University College of Veterinary Medicine) of the world have detected H1N1 Type A influenza virus sequences After analysis, the synthetic immune to the virus, an important gene (HA and NA genes), and cloned into the influenza virus reverse genetics system vector, sequencing results showed that the correct sequence of the recombinant with artificial genetic tag. Ongoing virus rescue work.

Guangdong swine did not find a flow dyeing

researchers from all over the large-scale farms in Guangdong were collected about a total of 1100 serum samples are currently being determined antibody levels. Guangdong is not found to be infected with a swine flow.

In addition, the collection of 325 clinical samples were inoculated SPF chicken embryo after treatment, the alpha未分离influenza H1N1 virus; with WHO recommended influenza A H1N1 influenza virus fluorescence quantitative PCR assay did not detect a influenza virus type H1N1-positive samples.

At present, the group of all the staff working hard to carry out epidemiological investigations and the pig, tracking pathogenic virus pathogenicity studies and vaccine forecasting early warning of drug research.